Fungicidal activity of amiodarone is tightly coupled to calcium influx
نویسندگان
چکیده
منابع مشابه
Membrane hyperpolarization drives cation influx and fungicidal activity of amiodarone.
Cationic amphipathic drugs, such as amiodarone, interact preferentially with lipid membranes to exert their biological effect. In the yeast Saccharomyces cerevisiae, toxic levels of amiodarone trigger a rapid influx of Ca(2+) that can overwhelm cellular homeostasis and lead to cell death. To better understand the mechanistic basis of antifungal activity, we assessed the effect of the drug on me...
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The antiarrhythmic drug amiodarone has microbicidal activity against fungi, bacteria and protozoa. In Saccharomyces cerevisiae, amiodarone triggers an immediate burst of cytosolic Ca, followed by cell death markers. Ca transients are a common response to many forms of environmental insults and toxic compounds, including osmotic and pH shock, endoplasmic reticulum stress, and high levels of mati...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2008
ISSN: 1567-1356
DOI: 10.1111/j.1567-1364.2008.00354.x